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However, there is also the contribution of entropy to the process. Research Articles Cholesterol Solubility in Organic Solvents G.L. Solubility of cholesterol & cholesteryl benzoate in some polar & nonpolar organic solvents. It depends on the amine and the organic solvent in question. Thus, cholesterol is more soluble in hexane. Flynn, * x Y. Shah, * S. Prakongpan, * K.H. Why is cholesterol more soluble in organic solvents than in water? Henceit is readily soluble in non polar solvents such as acetone and ethoxyethane. Hexane is an organic solvent, and it will dissolve compounds with virtually no electronegative groups. Well, "like dissolves like" so since cholesterol is an organic compound, it is more soluble in an organic solvent. That's why i want cholesterol which is soluble in water. Hence predominant intermolecular forces (solute-solute) are van der waals interactions. LiCl has sufficient covalent character because of greater polarisation. Organic solutes tend to have many C-H bonds for instance alkanes, benzene, which are non polar due to low electronegativity differences. Kwan, * W.I. I think that the answer is generally “yes” in the sense that for a given organic amine, you can find an organic solvent in which it is soluble. ... (0,3 mg cholesterol with 0.1-0.5 mL organic solvent) and add water to terminate the solution (99.9-99.5 mL water). Your Ad Here. Dissolution usually leads to an increase in disorder and hence an increase in entropy. Solubility of cholesterol in selected organic solvents. 1. Also, the structure of cholesterol doesn't lend itself to dissolving in water very well. Indian J Biochem Biophys. Fluid Phase Equilibria, 97: 191-200. Organic solvents are generally non polar as compared to polar solvents like water. Because of the contribution from the entropy, the overall energy change may be exothermic or endothermic. 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